What Is Thalassemia Syndrome?

What are the main causes of thalassemia?

Thalassemia is caused by mutations in the DNA of cells that make hemoglobin — the substance in red blood cells that carries oxygen throughout your body.

The mutations associated with thalassemia are passed from parents to children..

Is thalassemia a serious disease?

Alpha Thalassemia Major is a very serious disease in which severe anemia begins even before birth. Pregnant women carrying affected fetuses are themselves at risk for serious pregnancy and delivery complications. Another type of Alpha Thalassemia is Hemoglobin H disease.

What is the life expectancy of someone with thalassemia?

A person with the thalassemia trait has a normal life expectancy. However, heart complications arising from beta thalassemia major can make this condition fatal before the age of 30 years.

What is the most common form of thalassemia?

Beta thalassemia is a fairly common blood disorder worldwide. Thousands of infants with beta thalassemia are born each year. Beta thalassemia occurs most frequently in people from Mediterranean countries, North Africa, the Middle East, India, Central Asia, and Southeast Asia.

What is the best treatment for thalassemia?

Standard TreatmentsBlood Transfusions. Transfusions of red blood cells are the main treatment for people who have moderate or severe thalassemias. … Iron Chelation Therapy. The hemoglobin in red blood cells is an iron-rich protein. … Folic Acid Supplements. … Blood and Marrow Stem Cell Transplant. … Possible Future Treatments.

Can thalassemia cause leukemia?

Abstract. Occurrence of leukemia in thalassemia major is a rare presentation. Here we report two cases of thalassemic patients, developing acute lymphoblastic leukemia. The genetic analysis revealed that, female and male patients were homozygous for IVSI-6 and IVSI-5, respectively.

Is milk good for thalassemia?

Calcium. Many factors in thalassaemia promote calcium depletion. A diet containing adequate calcium (e.g. milk, cheese, dairy products and kale) is always recommended.

Does thalassemia weaken immune system?

Because of this, people with thalassemia are said to be “immunocompromised,” which means that some of the body’s defenses against infection aren’t working. When you are immunocompromised, it is easier for you to get infections and you sometimes need extra protection, like flu shots and other vaccines.

What should we eat in thalassemia?

Nutrition & Thalassemia Nutritional deficiencies are common in thalassemia. It is recommended that patients going through blood transfusion should opt for a low iron diet. Avoiding iron-fortified foods like cereal, red meat, green leafy vegetables & Vitamin C-rich foods is the best option for thalassemic patients.

What blood type is thalassemia?

What is thalassemia? Thalassemia is the name of a group of inherited blood disorders. There are two main types of thalassemia: alpha and beta, in reference to the alpha and beta proteins that form hemoglobin in the blood.

Can thalassemia be cured?

Blood transfusions and chelation do not cure beta thalassemia. A stem cell transplant can cure it, but it is a serious procedure with many risks and won’t benefit everyone with the condition. Doctors and scientist are working on developing gene therapies and other treatments to help people with beta thalassemia.

What organs does thalassemia affect?

Thalassemia can cause bone deformities in the face and skull. People who have thalassemia may also have severe osteoporosis (brittle bones). Too much iron in your blood. This can cause damage to the heart, liver, or endocrine system (glands in the body that make hormones, like the thyroid gland and adrenal glands).

Should I marry a thalassemia minor girl?

Can she conceive? A:A person, who is going to marry thalassemia minor, should check his/her thalassemia status before marriage to avoid the birth of thalassemia major. If both are thalassemia minor, there is 25% chances of thalassemia major in offspring, 25% chances of normal offspring and 50% chances of minor.

How do you fix thalassemia?

A stem cell transplant is the only treatment that can cure thalassemia. But only a small number of people who have severe thalassemias are able to find a good donor match and have the risky procedure. For more information, go to the Health Topics Blood and Marrow Stem Cell Transplant article.